Since Emile Zuckerkandl and Linus Pauling proposed their hypothesis of a “molecular evolutionary clock” in their seminal 1965 paper titled “Evolutionary Divergence and Convergence in Proteins,” biologists have been fascinated by the prospect of adding a temporal dimension to their inferences of evolutionary relationships of genes and organisms. This article is part of the PLOS Biology 20th Anniversary Collection. AR is a scientific consultant for LifeMine Therapeutics, Inc. JLS is a scientific advisor for WittGen Biotechnologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: JLS is a scientific consultant for Latch AI Inc. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Research in AR’s lab is supported by grants from the National Science Foundation (DEB-2110404), the National Institutes of Health/National Institute of Allergy and Infectious Diseases (R01 AI153356), and the Burroughs Wellcome Fund. PLoS Biol 21(1):Ĭopyright: © 2023 Steenwyk, Rokas. Citation: Steenwyk JL, Rokas A (2023) The dawn of relaxed phylogenetics.
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